I like web.py, mainly because it's simple and quite pythonic. I wanted a fancy multiple file upload page - however docs on uploading multiple files were a bit flaky. Here is what I came up with.

import web
import os

URLS = ('/upload', 'Upload')
APP = web.application(URLS, globals())

class Upload:
    def GET(self):
        return """
            <html>
            <form method="POST" enctype="multipart/form-data" action="">
            Select files: <input type="file" name="upload" multiple>
            <input type="submit">
            </form>
            </html>
            """

    def POST(self):

        files = web.webapi.rawinput().get('upload')

        if not isinstance(files, list):
            files = [files]

        for f in files:
            # in my case, i want files to go to static/media
            target = os.path.join('static', 'media', f.filename)
            content = f.file.read()
            with open(target, 'w') as f:
                f.write(content)

        return


if __name__=='__main__':
    APP.run()